Basically, Phentermine is a weaker relative to amphetamine. At low, therapeutic doses, these drugs bind to the presynaptic membrane of dopamine neurons thus inducing the release of dopamine. They then bind to to block the dopamine reuptake and storage vesicle pumps and actually reverse the direction of the transporters so that even more dopamine is released from the neuron, they take any extra dopamine in the neuron and diffuse it through the nerve terminal (axon) and, at high doses, through impromptu channels leading out of the neuron. The same is done to norepinephrine except there is only one reuptake pump doing both functions (NET).
There is a new combination drug called Qysmia that contains both phentermine and the only anti-convulsant that has a weight loss effect. The clinical trials of Qysmia were so successful with 87% losing significant weight over a year, The FDA approved its use for a year unlike phentermine alone or other anti-obesity drugs which are limited for use in two weeks. Travis
What is Phentermine?
Phentermine is a short-term weight loss drug that has been approved by the Food and Drug Administration (FDA) for use up to 12 weeks by adults over 16.
It is usually prescribed to people who are overweight with a BMI over 27, and at least one weight-related condition such as high blood pressure, high cholesterol, or diabetes.
Phentermine works by increasing chemical messages in the brain that signal to the body that it is full. This leads the person to eat less and thus lose weight, they would have otherwise gained.
It’s important to reiterate that is not a stand-alone solution to weight problems, rather it is a pill to be taken only when prescribed by a doctor, and should be taken alongside a healthy diet, and regular exercise.
Does Phentermine really work?
Phentermine makes you feel full, thereby suppressing your appetite and urge to eat. This results in a reduction in the calories that you consume and weight loss.
The amount of weight loss will depend on factors such as whether you are also eating healthily and exercising to burn off calories.
Phentermine is regarded as a drug that will aid your weight loss results, but not work on its own.
A study found that Phentermine combined with a meal replacement program resulted in a loss in food cravings and lost more weight than those who just cut out a meal a day.
The typical average weight loss for people who take phentermine over 12 weeks can be as high as 10%. In a 90k person, this can translate into 9kg of weight loss.
Another study that compared a group who took an average dose of 27.5mg of phentermine over 13 weeks with a group who didn’t take it, found that the group who took the drug lost an average of 13.9 pounds compared to 6.2 pounds for those that didn’t take it.
When to take it?
Phentermine should only be used by people who are clinically diagnosed as obese (BMI should be over 30) and prescribed it by a doctor.
It is recommended for those people who struggle to lose weight with a diet and exercise, and need something to help.
Even when it is prescribed, phentermine is not intended to be used on its own, but rather alongside a healthier diet and more active lifestyle.
Crucially, Phentermine is not meant to be taken by ordinary people who are looking to lose a few pounds.
Each person who is prescribed the drug is given a specific dosage to follow over a short period of time, usually no longer than 12 weeks.
Having said that, the FDA has approved a drug combination of phentermine with topiramate for long term use, as the dosage when combined is lower than when they are on their own.
How good is phentermine for losing weight?
When prescribed by a doctor and used as directed it can, apparently, help. Nobody should take Phentermine except under medical supervision because of the risks and side effects.
In reality, no drug is needed to lose weight. All it’s doing is helping the person maintain a calorie deficit, which is what actually causes the weight loss. That can be done for free and without drugs by improving your relationship with food. See
How does Phentermine Work?
Phentermine works by increasing the level of 3 specific neurotransmitters: Norepinephrine, Serotonin, and Dopamine. All these naturally occur in the body, but for some people (for whatever reason) the flow levels could be lower than normal. They seem to gain weight faster than others. Phentermine tends to solve those problems. Following are the specific descriptions of what they do to the body:
- Norepinephrine or Epinephrine: People know it as Adrenalin or Epi. It is a metabolizer. An increase in the level of Epi tells the brain to request more energy. It is actually a stress hormone and prepares the body for a ‘fight-or-flight’ response. The body then reacts to it by burning fatty cells to release energy.
- Serotonin: Serotonin is a versatile hormone. Of its many functions, one is the control of the digestive tract. It signals the brain when we are full. We’d continuously eat if it wasn’t for Serotonin. This is the appetite suppressant.
- Dopamine: It’s the reward hormone. A huge amount of Dopamine is released after sex. It tells the brain to relax and gives us a happy feeling. The release of this neurotransmitter is necessary for two reasons. Firstly, the release of Adrenalin can stress the body, and people might have anxiety or panic attacks due to the ‘fight-or-flight’ response. Dopamine is there to tell the brain that ‘Everything is fine’. Secondly, a short-term stress response is good so that our body releases energy. Long-term stress has the opposite effect. Our body has a built-in defense mechanism that conserves energy to be used later. If the stress lasts long, the body starts to conserve energy instead of releasing it. That means that you can even gain more weight in the long run. That’s the reason people eat more while under stress. Dopamine controls it so that Serotonin and Norepinephrine can do their jobs.
While there is no real substitute for a healthy, well-balanced diet and regular exercise, drugs such as phentermine may help those who struggle to lose weight through these methods alone.
Phentermine has been proven as an effective short-term weight loss pill alongside a lower-calorie diet and exercise, so it is unsurprising that it is one of the most popular drugs for weight loss.
However, using phentermine domes come with some risks and side-effects.
In this article, we will cover exactly what phentermine is, whether as has been claimed, it can really work for weight loss, as well as the risks and possible side effects.
How Phentermine works in appetite control
You may find out that phentermine helps for about 2 weeks, then the effect on appetite control fades away. Like many stimulants, phentermine is subject to “tachyphylaxis” which means your own system gets used to it. It may work longer, but be prepared to have some other maneuver ready like especially high-fiber foods, vegetarian meals or all-liquid diet. Of course, portion control works all the time
As with most drugs, Phentermine does have risks associated with it, hence the need to consult with a doctor and have a prescription before taking it.
Possible side effects
- Sleeping problems
- Dry mouth
- Heart palpitations
- Shortness of breath
In addition to this, Phentermine shouldn’t be taken by pregnant women or people with long-term diseases such as diabetes or heart disease.
Weight loss tips
While Phentermine can be helpful to people who are really struggling with weight loss, it is a short-term approach.
For lasting, long-term weight loss, the most powerful approach is to change the way you eat and exercise regularly.
Without making changes to your lifestyle, it’s highly likely that you will regain the weight you lost taking Phentermine.
Some ideas/tips for a healthy lifestyle include:
- Lower your carb intake: Cut down on carb-heavy foods such as white rice and pasta and replace them with whole foods and lean meats.
- Lower your calorie consumption: To lose weight you need to have a calorie deficit so you burn more calories than you consume. To achieve this, you need to track what you eat and go for lower calorie foods.
- Eat plenty of fruit and vegetables
- Stay well-hydrated
- Cut out high-sugar drinks and alcohol
- Exercise regularly: Try to incorporate both a cardio and strength resistance training regime into your weekly schedule. Note, this doesn’t mean you have to join a gym. For cardio exercise ideas, you can do at home see here. For strength resistance training suggestions at home see here.
- Learn how to relax
- Get a good night’s sleep
- Take a weight loss supplement
Phentermine is an FDA approved weight loss suppressant with proven results, but should only be taken if prescribed by a doctor, and will only be suitable for certain individuals.
Taken alone, it is unlikely to be as effective as one desires.
The best results will come when combined with a healthy well-balanced diet that is combined with regular exercise.
For more weight loss tips check out these article